What is Methylprednisolone?

Methylprednisoloneis is sold under its generic name as well as its brand names; Medrol, and Medrol Dosepak. It is a steroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used in the treatment of many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Important Information about Methylprednisolone

If you have a fungal infection anywhere in your body do not use Methylprednisolone.

Tell your doctor about all of your medical conditions, and about all other medicines you are using before starting a treatment regimen with Methylprednisolone. This is because the medication is known to affect many other disease and medications that could be a risk to your health and safety.

It is important to tell your doctor about any illness or infection you have had within the past several weeks. Methylprednisolone, just as with other steroid medications, can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Try to avoid sick people when taking Methylprednisolone to avoid any infection.

Do not suddenly stop using Methylprednisolone. This can result in unpleasant withdrawal symptoms. Talk to your Doctor to be weened of the medication gradually before stopping its use.

 

Methylprednisolone Side Effects

Along with the desired effects of Methylprednisolone there are often side effects associated with this medication. Most commonly patients will experience an increased appetite. If you experience any of the following side effects contact your prescribing physician immediately;

  • Aggression
  • agitation
  • anxiety
  • blurred vision
  • decrease in the amount of urine
  • dizziness
  • fast, slow, pounding, or irregular heartbeat or pulse
  • headache
  • irritability
  • mental depression
  • mood changes
  • nervousness
  • noisy, rattling breathing
  • numbness or tingling in the arms or legs
  • pounding in the ears
  • shortness of breath
  • swelling of the fingers, hands, feet, or lower legs
  • trouble thinking, speaking, or walking
  • troubled breathing at rest
  • weight gain

 

Methylprednisolone Use

Methylprednisolone is used in the treatment of many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells. This medication works by preventing the release of substances in the body that cause inflammation.

Methylprednisolone Dosage and Directions

 

Usual Adult Dose for:

  • Allergic Rhinitis – acetate: 80 to 120 mg intramuscular only.
  • Dermatologic Lesion – acetate: 40 to 120 mg intramuscular weekly for 1 to 4 weeks.
  • Rheumatoid Arthritis – Acetate: 40 to 120 mg intramuscular weekly – Large joints: 20 to 80 mg intraarticular – Medium joints: 10 to 40 mg intraarticular – Small joints: 4 to 10 mg intraarticular
  • Adrenogenital Syndrome – Acetate: 40 mg intramuscular every 2 weeks.
  • Anti-inflammatory – 4 to 48 mg/day orally. – Sodium succinate: 10 to 40 mg Intravenous over 1 to several minutes. Give subsequent doses IV or IM.
  • Shock – 30 mg/kg IV repeated every 4 to 6 hours or 100 to 250 mg IV repeated every 2 to 6 hours.
  • Immunosuppression – 4 to 48 mg orally per day. – 2 to 2.5 mg/kg per day IV or IM, tapered slowly over 2 to 3 weeks or 250 to 1,000 mg IV once daily or on alternate days for 3 to 5 doses.
  • Acute Asthma – Oral or IV: 40 to 80 mg/day in divided doses 1 to 2 times/day until peak expiratory flow is 70% of predicted or personal best
  • Asthma Maintenance – Oral: 7.5 to 60 mg daily given as a single dose in the morning or every other day as needed for asthma control

Usual Pediatric Dose for:

  • Anti-inflammatory – Sodium succinate: not less than 0.5 mg/kg/24 hours intravenous or intramuscular. – High dose therapy: 30 mg/kg intravenous over 10 to 20 minutes. May repeat every 4 to 6 hours, but not beyond 48 to 72 hours.
  • Acute Asthma – Ages 11 and under, Oral or IV: 1 to 2 mg/kg/day in 2 divided doses (maximum: 60 mg/day) until peak expiratory flow is 70% of predicted or personal best. – Aver 11 and older, Oral or IV: 40 to 80 mg/day in divided doses 1 to 2 times/day until peak expiratory flow is 70% of predicted or personal best
  • Asthma Maintenance – Ages 11 and under, 0.25 to 2 mg/kg/day given as a single dose in the morning or every other day as needed for asthma control; maximum dose: 60 mg/day. – Ages 11 and older, Oral: 7.5 to 60 mg orally daily given as a single dose in the morning or every other day as needed for asthma control.